CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings
Seppala TT et al. – Amyloid plaques and hyperphosphorylated tau in cortical brain biopsies are reflected by low CSF Aβ42 and high CSF tau and p–tau levels, respectively.Methods
- In 182 patients with presumed normal pressure hydrocephalus (152 with known APOE carrier status), Aβ plaques and tau in the cortical brain biopsies were correlated with the ventricular and lumbar CSF Aβ 42, total tau, and p-tau levels measured by ELISA.
- In a median follow-up of 2.0 years, 51 patients developed AD dementia.
- The patients with Aβ plaques in the cortical biopsy had lower (p =0.009) CSF Aβ 42 levels than those with no Aβ plaques.
- The patients with tau in the cortical biopsy had lower (p = 0.014) Aβ 42 but higher (p=0.015) p-tau 181 in CSF as compared to those with no tau in the cortical biopsy.
- The patients with amyloid + tau + biopsies had the lowest Aβ 42 and highest tau and p-tau 181 levels in CSF.
- The Aβ 42 levels were lower and the tau and p-tau 181 higher in the ventricular vs corresponding lumbar CSF samples.
- In multivariate analysis, the presence of cortical Aβ was independently predicted by the APOE ε4 carrier status and age but not by CSF Aβ 42 or tau levels.