Long-term use of antiplatelet drugs by stroke patients: a follow-up study based on prescription register data
European Journal of Clinical Pharmacology,  Clinical Article

Ostergaard K et al. – Long–term non–persistence with antiplatelet treatment was high and more pronounced in the patients with less severe stroke. The findings on the use of acetylsalicylic acid (ASA) and dipyridamole indicate that non–persistence may in part be amenable to simple intervention measures.

Methods
  • Population–based prescription register data were used to determine antiplatelet drug use in a cohort of stroke patients discharged from a Danish neurology department.
  • The antiplatelet drugs comprised acetylsalicylic acid (ASA), clopidogrel and dipyridamole (if combined with ASA use).
  • Non–persistence was defined as failure to present a prescription for antiplatelet drugs within 180 days after the dosage of a previous prescription had run out, or within 180 days after discharge.
  • Cox regression was used to identify risk factors for non–persistence.

Results
  • The cohort comprised 503 patients with ischaemic stroke discharged in 1999–2001.
  • During follow–up (median 2.8 years, interquartile range 0.8–7.8 years), 486 of the subjects presented prescriptions for antiplatelets.
  • Most subjects used a dual regimen of ASA and dipyridamole (N=320).
  • Of 110 non–persistent subjects in this group, 64 stopped using ASA, but continued to use dipyridamole in monotherapy.
  • Overall, 181 patients (36 %) were non–persistent.
  • Stroke severity was inversely associated with the risk of non–persistence [NIHSS score on admission 0–3 (reference); 4–6: hazard risk (HR) 0.87, 95 % confidence interval (CI) 0.61–1.25; 7+: HR 0.47, 95 % CI 0.29–0.74].

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Nursing

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Nursing Articles

1 Yogurt consumption, weight change and risk of overweight/obesity: The SUN cohort study Nutrition, Metabolism & Cardiovascular Diseases, July 28, 2014    Clinical Article

2 Blood pressure in relation to coffee and caffeine consumption Current Hypertension Reports, August 8, 2014    Review Article

3 Vitamin D and sleep disorders Full Text Nature and Science of Sleep, August 13, 2014    Free full text    Clinical Article

4 Long-term associations of nut consumption with body weight and obesity American Journal of Clinical Nutrition, June 23, 2014    Clinical Article

5 Yogurt and weight management American Journal of Clinical Nutrition, April 3, 2014    Review Article

6 California trees nailed as the source of mystery infections Duke University Health & Medicine News, August 26, 2014

7 Egg consumption is associated with increased risk of ovarian cancer: Evidence from a meta-analysis of observational studies Clinical Nutrition, August 5, 2014    Evidence Based Medicine

8 Chocolate intake and diabetes risk Clinical Nutrition, July 21, 2014    Clinical Article

9 Vitamin D and melanoma and non-melanoma skin cancer risk and prognosis: A comprehensive review and meta-analysis European Journal of Cancer, August 7, 2014    Review Article

10 Unprecedented number of medical staff infected with Ebola WHO news, August 27, 2014

11 Metformin in chronic kidney disease: Time for a rethink Peritoneal Dialysis International, July 9, 2014    Clinical Article

12 Vitamin D and the risk of dementia and Alzheimer's disease Neurology®, August 27, 2014    Clinical Article

13 A new “whey” to control diabetes American Friends of Tel Aviv University Medicine and Health News, August 6, 2014

14 Effects of tea intake on blood pressure: A meta-analysis of 21 randomized controlled trials JACC - Journal of the American College of Cardiology, October 22, 2014    Clinical Article

15 Associations of sugar and artificially sweetened soda and chronic kidney disease: A systematic review and meta-analysis Nephrology, September 24, 2014    Evidence Based Medicine    Review Article

16 Effect of ginger (Zingiber officinale) on heavy menstrual bleeding: a placebo-controlled, randomized clinical trial Phytotherapy Research, October 13, 2014    Clinical Article

17 Habitual intake of fruit juice predicts central blood pressure Appetite, October 24, 2014    Clinical Article

18 Fish consumption and risk of rheumatoid arthritis: A dose-response meta-analysis Arthritis Research & Therapy, October 7, 2014    Evidence Based Medicine    Review Article

19 Chocolate consumption and risk of heart failure in the Physicians Health Study European Journal of Heart Failure, October 17, 2014    Clinical Article

20 Black tea consumption and serum cholesterol concentration: Systematic review and meta-analysis of randomized controlled trials Clinical Nutrition, October 28, 2014    Evidence Based Medicine    Review Article

Indexed Journals in Nursing: Journal of Advanced Nursing, Journal of Clinical Nursing, Nurse Education In Practicemore