Identification of a Novel Binding Protein of FAT10: Eukaryotic Translation Elongation Factor 1A1
Digestive Diseases and Sciences, 05/18/2012
Yu X et al. – The authors propose a model in which eEF1A1 serves as a substrate of FAT10 to accomplish, in part, its functions in regulating the biological behavior of tumor cells. Since both eEF1A1 and FAT10 are important for tumorigenesis and development, comprehending the mechanisms of this interaction can provide clues for identification of novel strategic targets for drug screening and molecular typing, and possibly in the development of new effective therapeutic strategies against hepatocellular carcinoma.