mdlinx mdlinx
Latest (458) Full Text Articles (5583) Article Summary

A phase I trial of concurrent chemoradiotherapy with non-split administration of docetaxel and cisplatin for dry stage III non-small-cell lung cancer
Cancer Chemotherapy and Pharmacology,  Clinical Article

Hida N et al. – Concurrent chemoradiotherapy (cCRT) with non–split docetaxel (D) plus cisplatin (P) was a tolerable and effective regimen, and recommended dose (RD) was 50/80mg/m2 every 4weeks.

Methods
  • Patients (aged ≤70years) with unresectable dry stage III non-small-cell lung cancer (NSCLC) and having performance status 0 or 1 and adequate organ function were eligible.
  • They received radiotherapy (60 Gy in 30 fractions) once daily starting on day 2.
  • Concurrent P (day 1; 60mg/m2 at Levels 1–3, 80mg/m2 at Level 4) and D (day 1; 30mg/m2 at Level 1, 40mg/m2 at Level 2, 50mg/m2 at Levels 3–4) were administered every 4weeks for 2–4 courses.

Results
  • Eighteen patients were enrolled (stage IIIA/IIIB, 5/13 patients).
  • Three cases of dose-limiting toxicity were observed in this study, although another 3 cases were added at Levels 2 and 3.
  • Radiotherapy was completed in 15 patients.
  • Seventeen patients received more than 2 courses of chemotherapy.
  • Neither Grade 3/4 esophagitis nor severe hematological events were observed at Levels 1–4.
  • However, dose escalation to Level 5 (P [80mg/m2], D [60mg/m2]) was stopped because the Level 5 dose was the recommended dose (RD) of chemotherapy alone for stage IIIB/IV NSCLC in Japan.
  • Therefore, the RD was determined as D50/P80mg/m2 in this cCRT.
  • The objective response rate was 89 %, and the median survival time was 23.6months.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Nursing

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Nursing Articles

Last month's top read Top Articles of 2013

1 Ticks may cause double trouble, Stanford scientists find Full Text EurekAlert!, February 21, 2014    Free full text

2 'Putting the next generation of brains in danger' Full Text CNN Health, February 18, 2014    Free full text

3 How grazing affects your digestive function U.S. News & World Report - Health, January 30, 2014

4 A meta-analysis of coffee intake and risk of urolithiasis Urologia Internationalis, February 7, 2014    Clinical Article

5 Personal health: tackling menopauses side effects The New York Times, February 12, 2014

6 Yogurt consumption and impact on health: focus on children and cardiometabolic risk American Journal of Clinical Nutrition, March 21, 2014    Review Article

7 Long-term coffee consumption and risk of cardiovascular disease Circulation, February 11, 2014    Evidence Based Medicine    Review Article    Clinical Article

8 Tea consumption and leukemia risk: A meta-analysis Tumor Biology, February 12, 2014    Evidence Based Medicine    Clinical Article

9 Coffee intake and gastric cancer risk Cancer Epidemiology, Biomarkers & Prevention, March 19, 2014    Clinical Article

10 Effects of pomegranate juice consumption on inflammatory markers in patients with type 2 diabetes: A randomized, placebo-controlled trial Journal of Research in Medical Sciences, March 20, 2014    Clinical Article

11 Egg consumption and cardiovascular disease among diabetic individuals: A systematic review of the literature Full Text Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, March 28, 2014    Free full text    Review Article

12 Could you relationship with your mom increase your childs chances of obesity? Full Text EurekAlert!, February 3, 2014    Free full text

13 Coffee consumption and prostate cancer risk: An updated meta-analysis Cancer Causes and Control, March 3, 2014    Evidence Based Medicine    Clinical Article

14 Heated vegetable oils and cardiovascular disease risk factors Vascular Pharmacology, March 20, 2014    Review Article

15 Animal protein intake is associated with higher-level functional capacity in elderly adults: The Ohasama study Journal of the American Geriatrics Society, March 5, 2014    Clinical Article

16 Coffee consumption and risk of prostate cancer: A meta-analysis of prospective cohort studies Carcinogenesis, January 17, 2014    Evidence Based Medicine    Review Article

17 Vascular dysfunction and chronic obstructive pulmonary disease Hypertension, February 26, 2014    Clinical Article

18 Egg consumption and risk of GI neoplasms: dose–response meta-analysis and systematic review European Journal of Nutrition, February 6, 2014    Evidence Based Medicine    Review Article

19 Effects of yoga on cardiovascular disease risk factors: A systematic review and meta-analysis International Journal of Cardiology, March 17, 2014    Evidence Based Medicine    Review Article    Clinical Article

20 Is ginger effective for the treatment of irritable bowel syndrome? A double blind randomized controlled pilot trial Complementary Therapies in Medicine, March 4, 2014    Clinical Article

Indexed Journals in Nursing: Journal of Advanced Nursing, Journal of Clinical Nursing, Nurse Education In Practicemore

Other Topics in Nursing

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Stay current - Media Tool

Newsletter
RSS
Follow
Like

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close