Distinct genetic alterations in pediatric glioblastomas

Child's Nervous System, 05/14/2012

The study found two distinct pediatric glioblastomas (GBs) (pGBs) gene expression profiles: one similar to that of adult GBs (aGBs) and the other different. The authors identified significantly up– and down–regulated genes in pGBs that may provide better targets for diagnostic, prognostic, and therapeutic uses; however, more studies are required to determine the classification and optimal treatment of pediatric patients with GBs.

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