Metabolite Investigation in Both Anterior and Posterior Cingulate Gyri in Alzheimer’s Disease Spectrum Using 3-Tesla MR Spectroscopy
Dementia and Geriatric Cognitive Disorders, 05/31/2012
Lim TS et al. – Both the decreased N–acetylaspartate/creatine (NAA/Cr) of the posterior cingulate gyrus and the increased myoinositol/creatine (ml/Cr) of the anterior cingulate gyrus may reflect biochemical changes in Alzheimer’s disease (AD) according to the posterior–dominant progression of AD pathology.Methods
- Thirty-six patients with AD, 19 patients with amnestic mild cognitive impairment (aMCI), and 23 cognitively normal (CN) subjects were recruited.
- MR spectroscopy was conducted within the anterior and posterior cingulate gyri.
- A one-way analysis of co-variance was used to compare the metabolite ratios of each group and correlation analysis was used to show the correlation between the metabolite ratios with the Mini-Mental State Examination (MMSE) and Neuropsychiatric Inventory (NPI).
- The N-acetylaspartate/creatine (NAA/Cr) of the posterior cingulate gyrus was significantly higher in CN subjects than in aMCI and AD patients.
- On the other hand, the myoinositol/creatine (ml/Cr) of the anterior cingulate gyrus was significantly higher in AD patients than in CN subjects and aMCI patients.
- The ml/Cr of the posterior cingulate gyrus correlated with the MMSE and that of the anterior cingulate gyrus correlated with the NPI.