Biphasic effects of H. pylori infection on low-dose aspirin-induced gastropathy depending on the gastric acid secretion level
Journal of Gastroenterology,  Clinical Article

Iijima K et al. – The effect of H. pylori infection on the aspirin–induced gastropathy was biphasic depending on the individual gastric acid secretion level. In the presence of sufficient amounts of gastric acid, H. pylori infection and aspirin could synergistically damage gastric mucosal integrity, while in the absence of sufficient amounts of gastric acid, the synergistic effect could be completely counteracted and the infection could even suppress the aspirin–induced gastropathy.

Methods
  • Ninety–three (81 men, mean age: 70 years) long–term low–dose aspirin takers were prospectively enrolled.
  • H. pylori infection was evaluated by serum IgG antibody determination, and gastrin–stimulated acid output was assessed with the endoscopic gastrin test.
  • H. pylori–positive aspirin–takers were classified into 2 subgroups (hyposecretors and non–hyposecretors).
  • The grade of gastric mucosal injury was assessed endoscopically according to the modified Lanza score; intensive aspirin–induced gastropathy was defined as a modified Lanza score of ≥4.
  • Multiple logistic regression analyses were used to adjust for potential confounders.

Results
  • With H. pylori–negative patients taken as the reference, H. pylori infection was found to be positively associated with intensive gastropathy among non–hyposecretors, with an odds ratio (OR) (95 % confidence interval [CI]) of 4.2 (1.1–17.1), while the infection was negatively associated with gastropathy among hyposecretors, with an OR (95 % CI) of 0.3 (0.08–0.9).
  • Aspirin–induced gastropathy occurred preferentially in the antrum among H. pylori–positive non–hyposecretors, while it affected the fundus among H. pylori–positive hyposecretors.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Nursing

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Nursing Articles

1 Older brains slow due to greater experience, rather than cognitive decline Full Text EurekAlert!, January 22, 2014    Free full text

2 Yogurt and weight management American Journal of Clinical Nutrition, April 3, 2014    Review Article

3 Tea consumption and leukemia risk: A meta-analysis Tumor Biology, February 12, 2014    Evidence Based Medicine    Clinical Article

4 The effect of chromium supplementation on polycystic ovary syndrome in adolescents Journal of Pediatric and Adolescent Gynecology , May 30, 2014    Clinical Article

5 Effect of a low-flatulogenic diet in patients with flatulence and functional digestive symptoms Neurogastroenterology & Motility, February 25, 2014    Clinical Article
Exclusive Author Commentary

6 Do patients in a vegetative state recognize loved ones? Full Text EurekAlert!, December 18, 2013    Free full text

7 Long-term coffee consumption and risk of cardiovascular disease Circulation, February 11, 2014    Evidence Based Medicine    Review Article    Clinical Article

8 Egg consumption and insulin metabolism in the Insulin Resistance Atherosclerosis Study (IRAS) Public Health Nutrition, June 24, 2014    Clinical Article

9 Consumption of nuts and legumes and risk of incident ischemic heart disease, stroke, and diabetes: a systematic review and meta-analysis American Journal of Clinical Nutrition, June 19, 2014    Evidence Based Medicine    Review Article

10 Yogurt consumption, weight change and risk of overweight/obesity: The SUN cohort study Nutrition, Metabolism & Cardiovascular Diseases, July 15, 2014    Clinical Article

11 Ticks may cause double trouble, Stanford scientists find Full Text EurekAlert!, February 21, 2014    Free full text

12 Chikungunya poised to invade the Americas Full Text EurekAlert!, April 9, 2014    Free full text

13 Long-term associations of nut consumption with body weight and obesity American Journal of Clinical Nutrition, June 23, 2014    Clinical Article

14 Vitamin D status associated with multiple sclerosis activity, progression Full Text EurekAlert!, January 21, 2014    Free full text

15 Grape consumption may offer benefits for symptomatic knee osteoarthritis Full Text EurekAlert!, May 13, 2014    Free full text

16 The Mediterranean-style diet pattern and mortality among men and women with cardiovascular disease American Journal of Clinical Nutrition, November 1, 2013    Clinical Article

17 Chocolate intake and diabetes risk Clinical Nutrition, July 21, 2014    Clinical Article

18 Nut consumption for vascular health and cognitive function Nutrition Research Reviews, July 14, 2014    Review Article

19 Low-dose rapamycin (sirolimus) effects in autosomal dominant polycystic kidney disease: An open-label randomized controlled pilot study Clinical Journal of the American Society of Nephrology, May 23, 2014    Clinical Article

20 Yogurt consumption, weight change and risk of overweight/obesity: The SUN cohort study Nutrition, Metabolism & Cardiovascular Diseases, July 28, 2014    Clinical Article

Indexed Journals in Nursing: Journal of Advanced Nursing, Journal of Clinical Nursing, Nurse Education In Practicemore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close