Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes

Brain, 05/25/2012

The data suggest that the development of distal axonopathy in diabetic neuropathy is linked to nutrient excess and mitochondrial dysfunction via defective signalling of the adenosine monophosphate–activated protein kinase/peroxisome proliferator–activated receptor γ coactivator–1 α (PGC–1α) pathway.

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