Hypertonic Dextrose Injections (Prolotherapy) for Knee Osteoarthritis: Results of a Single-Arm Uncontrolled Study with 1-Year Follow-Up
The Journal of Alternative and Complementary Medicine,  Clinical Article

Rabago D et al. – In adults with moderate to severe KOA, dextrose prolotherapy may result in safe, significant, sustained improvement of knee pain, function, and stiffness scores. Randomized multidisciplinary effectiveness trials including evaluation of potential disease modification are warranted to further assess the effects of prolotherapy for knee osteoarthritis (KOA).

Methods
  • This was a prospective, uncontrolled study with 1–year follow–up.
  • The study was conducted in an outpatient setting.
  • Adults with at least 3 months of symptomatic KOA, recruited from clinical and community settings, participated in the study.
  • Participants received extra–articular injections of 15% dextrose and intra–articular prolotherapy injections of 25% dextrose at 1, 5, and 9 weeks, with as–needed treatments at weeks 13 and 17.
  • Primary outcome measure was the validated Western Ontario McMaster University Osteoarthritis Index (WOMAC).
  • Secondary outcome measure was the validated Knee Pain Scale (KPS).
  • Tertiary outcome measure was procedure–related pain severity and participant satisfaction.

Results
  • Thirty–six (36) participants (60±8.7 years old, 21 female) with moderate–to–severe KOA received an average of 4.3±0.7 prolotherapy injection sessions over a 17–week treatment period and reported progressively improved scores during the 52–week study on WOMAC and KPS measures.
  • Participants reported overall WOMAC score improvement 4 weeks after the first injection session (7.6±2.4 points, 17.2%), and continued to improve through the 52–week follow–up (15.9±2.5 points, p<0.001, 36.1%).
  • KPS scores improved in both injected (p<0.001) and uninjected knees (p<0.05).
  • Prescribed low–dose opioid analgesia effectively treated procedure–related pain.
  • Satisfaction was high and there were no adverse events. Female gender, age 46–65 years old, and body–mass index of 25 kg/m2 or less were associated with greater improvement on the WOMAC instrument.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Nursing

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Nursing Articles

1 Yogurt consumption, weight change and risk of overweight/obesity: The SUN cohort study Nutrition, Metabolism & Cardiovascular Diseases, July 28, 2014    Clinical Article

2 Blood pressure in relation to coffee and caffeine consumption Current Hypertension Reports, August 8, 2014    Review Article

3 Vitamin D and sleep disorders Full Text Nature and Science of Sleep, August 13, 2014    Free full text    Clinical Article

4 Long-term associations of nut consumption with body weight and obesity American Journal of Clinical Nutrition, June 23, 2014    Clinical Article

5 Yogurt and weight management American Journal of Clinical Nutrition, April 3, 2014    Review Article

6 California trees nailed as the source of mystery infections Duke University Health & Medicine News, August 26, 2014

7 Egg consumption is associated with increased risk of ovarian cancer: Evidence from a meta-analysis of observational studies Clinical Nutrition, August 5, 2014    Evidence Based Medicine

8 Chocolate intake and diabetes risk Clinical Nutrition, July 21, 2014    Clinical Article

9 Vitamin D and melanoma and non-melanoma skin cancer risk and prognosis: A comprehensive review and meta-analysis European Journal of Cancer, August 7, 2014    Review Article

10 Unprecedented number of medical staff infected with Ebola WHO news, August 27, 2014

11 Metformin in chronic kidney disease: Time for a rethink Peritoneal Dialysis International, July 9, 2014    Clinical Article

12 Vitamin D and the risk of dementia and Alzheimer's disease Neurology®, August 27, 2014    Clinical Article

13 A new “whey” to control diabetes American Friends of Tel Aviv University Medicine and Health News, August 6, 2014

14 Effects of tea intake on blood pressure: A meta-analysis of 21 randomized controlled trials JACC - Journal of the American College of Cardiology, October 22, 2014    Clinical Article

15 Associations of sugar and artificially sweetened soda and chronic kidney disease: A systematic review and meta-analysis Nephrology, September 24, 2014    Evidence Based Medicine    Review Article

16 Effect of ginger (Zingiber officinale) on heavy menstrual bleeding: a placebo-controlled, randomized clinical trial Phytotherapy Research, October 13, 2014    Clinical Article

17 Habitual intake of fruit juice predicts central blood pressure Appetite, October 24, 2014    Clinical Article

18 Fish consumption and risk of rheumatoid arthritis: A dose-response meta-analysis Arthritis Research & Therapy, October 7, 2014    Evidence Based Medicine    Review Article

19 Chocolate consumption and risk of heart failure in the Physicians Health Study European Journal of Heart Failure, October 17, 2014    Clinical Article

20 Black tea consumption and serum cholesterol concentration: Systematic review and meta-analysis of randomized controlled trials Clinical Nutrition, October 28, 2014    Evidence Based Medicine    Review Article

Indexed Journals in Nursing: Journal of Advanced Nursing, Journal of Clinical Nursing, Nurse Education In Practicemore