Smartest Doc
Obese Mexican American Children Have Elevated MCP-1, TNF-alpha, Monocyte Concentration, and Dyslipidemia
Pediatrics, 05/10/2012
Breslin WL et al. – Childhood obesity alters monocytes and circulating chemokines, putting children at a greater risk of developing obesity–related chronic diseases in adulthood. Further characterization of early immune alterations in childhood obesity may provide additional clinical insight into the assessment of obesity–related disease risk.
Methods- Blood samples were analyzed for total and subset monocyte concentration via flow cytometry.
- Serum monocyte chemoattractant protein-1 (MCP-1), fractalkine, interleukin-8, and tumor necrosis factor alpha (TNF-alpha) were measured by using a Milliplex MagPix assay.
- Serum cholesterol, high-density lipoproteins, triglycerides, and glucose were measured by using an enzymatic assay.
- Total monocyte concentration (P = .012), classic monocyte concentration (P = .045), MCP-1 (P = .015), and TNF-alpha (P = .002) were significantly greater in obese children compared with healthy weight children.
- Also, overweight and obese children had elevated triglycerides (P = .001) and reduced high-density lipoproteins (P = .033) compared with healthy weight children.
