Relation of interleukin-6 in rheumatoid arthritis patients to systemic bone loss and structural bone damage
Rheumatology International, 05/01/2012
Meguid MHA et al. – Patients with RA on steroid therapy had significantly lower T–score and lower serum ionized calcium than patients with RA not on steroid therapy. IL–6 has an important role in increasing osteoclastic activity and subsequent bone resorption in the patients with RA. Blocking IL–6 by using IL–6 inhibitors and anti–RANK–L therapy may be effective in inhibiting the inflammatory process and preventing the bone complications of RA disease.