Effect on short- and long-term major adverse cardiac events of statin treatment in patients with acute myocardial infarction and renal dysfunction
The American Journal of Cardiology,  Clinical Article

Lim SY et al. – Statin therapy reduced major adverse cardiac events (MACE) at 1 year of follow–up in patients with acute myocardial infarction (AMI) regardless of renal dysfunction (RD).

Methods
  • The 3–hydroxy–3–methylglutaryl–coenzyme A reductase inhibitors (statins) reduce major adverse cardiac events (MACE) and mortality in patients with acute coronary syndrome.
  • Authors investigated the effectiveness of statin therapy in reducing MACE in patients with acute myocardial infarction (AMI) and renal dysfunction (RD).
  • In the present retrospective study of 12,853 patients with AMI, the patients were categorized into 4 groups: group I, statin therapy and no RD (estimated glomerular filtration rate ≥60 ml/min/1.73 m2); group II, neither statin therapy nor RD; group III, statin therapy and RD; group IV, no statin therapy but RD.
  • The primary end points were death and complications during the hospital course.
  • The secondary end points were MACE during 1 year of follow–up after AMI.

Results
  • Significant differences in the composite MACE during 12 months of follow–up were observed among the 4 groups (group I, 11.7%; group II, 19.0%; group III, 26.7%; and group IV, 45.5%; p <0.001).
  • In a Cox proportional hazards model, mortality at 12 months increased stepwise from group II to IV compared to group I.
  • Moreover, MACE–free survival in the severe RD group (estimated glomerular filtration rate <30 mL/min/1.73 m2) was also greater in the statin–treated group.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Nursing

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Nursing Articles

1 Tea consumption and leukemia risk: A meta-analysis Tumor Biology, February 12, 2014    Evidence Based Medicine    Clinical Article

2 Effect of a low-flatulogenic diet in patients with flatulence and functional digestive symptoms Neurogastroenterology & Motility, February 25, 2014    Clinical Article
Exclusive Author Commentary

3 Egg consumption and insulin metabolism in the Insulin Resistance Atherosclerosis Study (IRAS) Public Health Nutrition, June 24, 2014    Clinical Article

4 Nut consumption and risk of type 2 diabetes, cardiovascular disease, and all-cause mortality: a systematic review and meta-analysis American Journal of Clinical Nutrition, June 4, 2014    Evidence Based Medicine    Review Article

5 Low-dose rapamycin (sirolimus) effects in autosomal dominant polycystic kidney disease: An open-label randomized controlled pilot study Clinical Journal of the American Society of Nephrology, May 23, 2014    Clinical Article

6 Long-term associations of nut consumption with body weight and obesity American Journal of Clinical Nutrition, June 23, 2014    Clinical Article

7 Yogurt consumption and impact on health: focus on children and cardiometabolic risk American Journal of Clinical Nutrition, March 21, 2014    Review Article

8 Fruits and vegetables consumption and risk of stroke Stroke, May 28, 2014    Evidence Based Medicine

9 A review of the effects of nuts on appetite, food intake, metabolism, and body weight American Journal of Clinical Nutrition, June 26, 2014    Review Article

10 Consumption of fruits, vegetables, and seaweeds (sea vegetables) and pancreatic cancer risk: The Ohsaki Cohort Study Cancer Epidemiology, May 5, 2014    Clinical Article

11 Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case–control study European Journal of Cancer Prevention, June 5, 2014    Clinical Article

12 Prognostic markers of sarcoidosis: An analysis of patients from everyday pneumological practice The Clinical Respiratory Journal, May 14, 2014    Clinical Article

13 Coffee consumption and prostate cancer risk: An updated meta-analysis Cancer Causes and Control, March 3, 2014    Evidence Based Medicine    Clinical Article

14 Meta-analysis of prospective studies on the effects of nut consumption on hypertension and type 2 diabetes mellitus Journal of Diabetes, June 10, 2014    Evidence Based Medicine

15 Fish consumption, sleep, daily functioning, and heart rate variability Journal of Clinical Sleep Medicine, June 12, 2014    Clinical Article

16 Consumption of nuts and legumes and risk of incident ischemic heart disease, stroke, and diabetes: a systematic review and meta-analysis American Journal of Clinical Nutrition, June 19, 2014    Evidence Based Medicine    Review Article

17 High-dose vitamin D supplementation and measures of insulin sensitivity in polycystic ovary syndrome: A randomized, controlled pilot trial Fertility and Sterility, May 6, 2014    Clinical Article

18 Suicide mortality in relation to dietary intake of n-3 and n-6 polyunsaturated fatty acids and fish: Equivocal findings from 3 large US cohort studies American Journal of Epidemiology, May 12, 2014    Clinical Article

19 Antibiotic prophylaxis for ED patients with simple hand lacerations: a feasibility randomized controlled trial The American Journal of Emergency Medicine, May 19, 2014    Clinical Article

20 Low vitamin D levels linked to disease in two big studies The New York Times, April 2, 2014

Indexed Journals in Nursing: Journal of Advanced Nursing, Journal of Clinical Nursing, Nurse Education In Practicemore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close