Differential features of muscle fiber atrophy in osteoporosis and osteoarthritis
Osteoporosis International, 05/08/2012
Terracciano C et al. – This study shows that in osteoporosis (OP), there is a preferential and diffuse type II fiber atrophy, proportional to the degree of bone loss, whereas in Osteoarthritis (OA), muscle atrophy is connected to the functional impairment caused by the disease. A reduction of Akt seems to be one of the mechanisms involved in OP–related muscle atrophy.
The authors performed muscle biopsy in 15 women with OP and in 15 women with OA (age range, 60–85 years).
Muscle fibers were counted, measured, and classified by ATPase reaction.
By statistical analysis, fiber–type atrophy was correlated with bone mineral density (BMD) in the OP group and with Harris Hip Score (HHS) and disease duration in the OA group.
Akt protein levels were evaluated by Western blot analysis.
The findings revealed in OP a preferential type II fiber atrophy that inversely correlated with patients’ BMD.
In OA, muscle atrophy was of lower extent, homogeneous among fiber types and related to disease duration and HHS.
Moreover, in OP muscle, the Akt level was significantly reduced as compared to OA muscles.
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