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Adipokines and metabolic syndrome risk-factors in women with previous gestational diabetes mellitus
Diabetes/Metabolism Research and Reviews, 05/14/2012
Roca–Rodriguez MM et al. – Women with previous Gestational diabetes mellitus (GDM) have central adiposity, atherogenic lipid profile, carbohydrate intolerance and adverse adipokine profile; all being of which are risk factors for the future development of metabolic and cardiovascular disease.
Methods- Women (n=41) with GDM background (cases) and 21 healthy women (controls) in the postpartum period were enrolled.
- Demographic and clinical data, lipid and carbohydrate metabolism, uric acid and adipokine levels (TNF-α, IL-6, leptin and adiponectin) were compared and their relationships analyzed.
- MetS prevalence was calculated by WHO and NCEP-ATPIII definitions.
- There were significant differences between cases and controls: body mass index (BMI; kg/m2) 27.4 ± 5.6 vs. 23.9 ± 3.6 (p=0.013); waist circumference (WC; cm) 85.2 ± 12.9 vs. 77.5 ± 9.0 (p=0.017); MetS (WHO definition) 14.6% vs. 0% (p = 0.012); MetS (NCEP-ATPIII definition) 22% vs. 0% (p=0.002), low-HDL 36.6% vs. 9.5% (p=0.024); fasting glucose (mmol/L) 5.4 ± 0.6 vs. 4.9 ± 0.2 (p<0.001), glucose 120' OGTT (mmol/L) 5.8 ± 1.7vs. 4.7 ± 0.8 (p=0.007); fasting insulin (μU/ml) 13.4 ± 8.1 vs. 8.4 ± 4.3 (p=0.004); HOMA index 3.3 ± 2.3 vs. 1.8 ± 1.0 (p=0.002); HbA1c (%) 5.4 ± 0.2 vs. 5.2 ± 0.2 (p=0.021); uric acid (mg/dL) 4.1 ± 1 vs. 3.5 ± 0.6 (p=0.009); leptin (ng/ml) 32025.5 ± 19917.3 vs. 20258.9 ± 16359.9 (p=0.023), respectively.
