Effects of telmisartan on cognition and regional cerebral blood flow in hypertensive patients with Alzheimers disease
Geriatrics and Gerontology International,  Clinical Article

Kume K et al. – The findings suggest that telmisartan may have additional benefits and be useful for the treatment of elderly hypertensive patients with Alzheimer's disease (AD).

Methods
  • A total of 20 patients with probable AD and essential hypertension were randomly assigned to the telmisartan group (n=10, 40-80 mg daily) or the amlodipine group (n=10, 5-10 mg daily) for 6 months.

Results
  • The groups had a similar significant reduction in systolic and diastolic blood pressure after treatment.
  • The telmisartan group did not show any changes in cognitive function test scores, while the amlodipine group showed significantly higher scores on the AD Assessment Scale-Cognitive Subscale (Japanese version).
  • Analysis of covariance to analyze treatment effect revealed that the telmisartan group showed increased rCBF in the right supramarginal gyrus, superior parietal lobule, cuneus, and lingual gyrus compared with the amlodipine group, while the amlodipine group showed increased rCBF only in the right cingulate gyrus compared with the telmisartan group at 6 months.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Nursing

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Nursing Articles

1 Tea consumption and leukemia risk: A meta-analysis Tumor Biology, February 12, 2014    Evidence Based Medicine    Clinical Article

2 Effect of a low-flatulogenic diet in patients with flatulence and functional digestive symptoms Neurogastroenterology & Motility, February 25, 2014    Clinical Article
Exclusive Author Commentary

3 Egg consumption and insulin metabolism in the Insulin Resistance Atherosclerosis Study (IRAS) Public Health Nutrition, June 24, 2014    Clinical Article

4 Nut consumption and risk of type 2 diabetes, cardiovascular disease, and all-cause mortality: a systematic review and meta-analysis American Journal of Clinical Nutrition, June 4, 2014    Evidence Based Medicine    Review Article

5 Low-dose rapamycin (sirolimus) effects in autosomal dominant polycystic kidney disease: An open-label randomized controlled pilot study Clinical Journal of the American Society of Nephrology, May 23, 2014    Clinical Article

6 Long-term associations of nut consumption with body weight and obesity American Journal of Clinical Nutrition, June 23, 2014    Clinical Article

7 Yogurt consumption and impact on health: focus on children and cardiometabolic risk American Journal of Clinical Nutrition, March 21, 2014    Review Article

8 Fruits and vegetables consumption and risk of stroke Stroke, May 28, 2014    Evidence Based Medicine

9 A review of the effects of nuts on appetite, food intake, metabolism, and body weight American Journal of Clinical Nutrition, June 26, 2014    Review Article

10 Consumption of fruits, vegetables, and seaweeds (sea vegetables) and pancreatic cancer risk: The Ohsaki Cohort Study Cancer Epidemiology, May 5, 2014    Clinical Article

11 Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case–control study European Journal of Cancer Prevention, June 5, 2014    Clinical Article

12 Prognostic markers of sarcoidosis: An analysis of patients from everyday pneumological practice The Clinical Respiratory Journal, May 14, 2014    Clinical Article

13 Coffee consumption and prostate cancer risk: An updated meta-analysis Cancer Causes and Control, March 3, 2014    Evidence Based Medicine    Clinical Article

14 Meta-analysis of prospective studies on the effects of nut consumption on hypertension and type 2 diabetes mellitus Journal of Diabetes, June 10, 2014    Evidence Based Medicine

15 Fish consumption, sleep, daily functioning, and heart rate variability Journal of Clinical Sleep Medicine, June 12, 2014    Clinical Article

16 Consumption of nuts and legumes and risk of incident ischemic heart disease, stroke, and diabetes: a systematic review and meta-analysis American Journal of Clinical Nutrition, June 19, 2014    Evidence Based Medicine    Review Article

17 High-dose vitamin D supplementation and measures of insulin sensitivity in polycystic ovary syndrome: A randomized, controlled pilot trial Fertility and Sterility, May 6, 2014    Clinical Article

18 Suicide mortality in relation to dietary intake of n-3 and n-6 polyunsaturated fatty acids and fish: Equivocal findings from 3 large US cohort studies American Journal of Epidemiology, May 12, 2014    Clinical Article

19 Antibiotic prophylaxis for ED patients with simple hand lacerations: a feasibility randomized controlled trial The American Journal of Emergency Medicine, May 19, 2014    Clinical Article

20 Low vitamin D levels linked to disease in two big studies The New York Times, April 2, 2014

Indexed Journals in Nursing: Journal of Advanced Nursing, Journal of Clinical Nursing, Nurse Education In Practicemore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close