Late Nonalcoholic Fatty Liver Disease with Cirrhosis: A Pathologic Case of Lost or Mistaken Identity
Seminars in Liver Disease,  Clinical Article

Lefkowitch JH et al. – A strategic pathologic approach is discussed, which can be utilized for the pathologic assessment of cirrhosis of unknown cause, particularly when late nonalcoholic fatty liver disease (NAFLD) is suspected.

  • Late-stage nonalcoholic fatty liver disease (NAFLD) may present clinically and/or pathologically as cryptogenic cirrhosis.
  • The subject of this report, a middle-aged obese man with diabetes, underwent liver biopsy at the time of laparoscopic cholecystectomy because the liver surface appeared nodular and thickened.
  • The biopsy showed relatively nondescript cirrhosis at initial low-power microscopic inspection, but glycogenated hepatocyte nuclei (consistent with diabetes), sparse macrovesicular fat, and very rare foci of residual mild steatohepatitis were later found.
  • Slender fibrous septa (without significant inflammation and often enclosing microvessels) were present and interconnected to portal tracts.
  • Immunostains for cytokeratin 7, ubiquitin, and glutamine synthetase provided additional histologic data supporting NAFLD as the cause of the cirrhosis in this case.

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Nursing

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Nursing Articles

1 Yogurt consumption, weight change and risk of overweight/obesity: The SUN cohort study Nutrition, Metabolism & Cardiovascular Diseases, July 28, 2014    Clinical Article

2 Blood pressure in relation to coffee and caffeine consumption Current Hypertension Reports, August 8, 2014    Review Article

3 Vitamin D and sleep disorders Full Text Nature and Science of Sleep, August 13, 2014    Free full text    Clinical Article

4 Long-term associations of nut consumption with body weight and obesity American Journal of Clinical Nutrition, June 23, 2014    Clinical Article

5 Yogurt and weight management American Journal of Clinical Nutrition, April 3, 2014    Review Article

6 California trees nailed as the source of mystery infections Duke University Health & Medicine News, August 26, 2014

7 Egg consumption is associated with increased risk of ovarian cancer: Evidence from a meta-analysis of observational studies Clinical Nutrition, August 5, 2014    Evidence Based Medicine

8 Chocolate intake and diabetes risk Clinical Nutrition, July 21, 2014    Clinical Article

9 Vitamin D and melanoma and non-melanoma skin cancer risk and prognosis: A comprehensive review and meta-analysis European Journal of Cancer, August 7, 2014    Review Article

10 Unprecedented number of medical staff infected with Ebola WHO news, August 27, 2014

11 Metformin in chronic kidney disease: Time for a rethink Peritoneal Dialysis International, July 9, 2014    Clinical Article

12 Vitamin D and the risk of dementia and Alzheimer's disease Neurology®, August 27, 2014    Clinical Article

13 A new “whey” to control diabetes American Friends of Tel Aviv University Medicine and Health News, August 6, 2014

14 Effects of tea intake on blood pressure: A meta-analysis of 21 randomized controlled trials JACC - Journal of the American College of Cardiology, October 22, 2014    Clinical Article

15 Associations of sugar and artificially sweetened soda and chronic kidney disease: A systematic review and meta-analysis Nephrology, September 24, 2014    Evidence Based Medicine    Review Article

16 Effect of ginger (Zingiber officinale) on heavy menstrual bleeding: a placebo-controlled, randomized clinical trial Phytotherapy Research, October 13, 2014    Clinical Article

17 Habitual intake of fruit juice predicts central blood pressure Appetite, October 24, 2014    Clinical Article

18 Fish consumption and risk of rheumatoid arthritis: A dose-response meta-analysis Arthritis Research & Therapy, October 7, 2014    Evidence Based Medicine    Review Article

19 Chocolate consumption and risk of heart failure in the Physicians Health Study European Journal of Heart Failure, October 17, 2014    Clinical Article

20 Black tea consumption and serum cholesterol concentration: Systematic review and meta-analysis of randomized controlled trials Clinical Nutrition, October 28, 2014    Evidence Based Medicine    Review Article

Indexed Journals in Nursing: Journal of Advanced Nursing, Journal of Clinical Nursing, Nurse Education In Practicemore