Distinct Properties of Circulating CD8+ T Cells in FTY720-Treated Patients With Multiple Sclerosis
JAMA Neurology, 12/17/2010
Johnson TA et al. – Therapy with FTY720 results in a subset of CD8+ T cells with distinct functional migratory properties dominating the peripheral circulation. The expected forthcoming use of FTY720 as a sustained therapy for Multiple Sclerosis will clarify how this redistribution of lymphocyte populations affects the overall process of immune surveillance.