Measles-Containing Vaccines and Febrile Seizures in Children Age 4 to 6 Years

Pediatrics, 05/14/2012

Klein NP et al. – This study provides reassurance that MMRV and MMR + V were not associated with increased risk of febrile seizures among 4– to 6–year–olds.

Methods

  • Among 4- to 6-year-old Vaccine Safety Datalink members, they identified seizures in the emergency department and hospital from 2000 to 2008 and outpatient visits for fever from 2006 to 2008 during days 7 to 10 and 0 to 42 after MMRV and MMR + V.
  • Incorporating medical record reviews, they assessed seizure risk after MMRV and MMR + V.

Results

  • From 2006 through 2008, 86?750 children received MMRV; from 2000 through 2008, 67438 received same-day MMR + V.
  • Seizures were rare throughout days 0 to 42 without peaking during days 7 to 10.
  • There was 1 febrile seizure 7 to 10 days after MMRV and 0 after MMR + V.
  • Febrile seizure risk was 1 per 86750 MMRV doses and 0 per 67438 MMR + V doses.

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