Glucose metabolism in small subcortical structures in Parkinsons disease

Acta Neurologica Scandinavica, 05/08/2012

The presence and extent of subcortical hypermetabolism in Parkinson’s disease (PD) is dependent on type of normalization. However, the present findings suggest that PD, in addition to widespread cortical hypometabolism, is probably characterized by true hypermetabolism in the external pallidum (GPe). This finding was predicted by the experimental model 2–deoxyglucose autoradiography literature, in which high–magnitude hypermetabolism was also most robustly detected in the GPe.

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