Trimetazidine reduces endogenous free fatty acid oxidation and improves myocardial efficiency in obese humans
Cardiovascular Therapeutics, 04/30/2012Bucci M et al.
In obese subjects, authors demonstrate that myocardial intracellular triglyceride oxidation significantly provides FA–derived energy for mechanical work. Trimetazidine (TMZ) reduced the oxidation of triglyceride–derived myocardial FAs improving myocardial efficiency.
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