Modest reversal of metabolic syndrome manifestations with vitamin D status correction: a 12-month prospective study
Metabolism, 11/11/2011AlDaghri NM et al. –
Optimization of vitamin D status through sun exposure and increased intake of a vitamin D–rich diet can lead to an improved cardiometabolic profile, offering a promising nonpharmacologic approach in the prevention of metabolic syndrome (MetS) manifestations.
A total of 59 adult nondiabetic, overweight, and obese Saudis (31 male, 28 female) were prospectively enrolled in this 1–year interventional study.
Anthropometry and biochemical evaluation were performed, including determination of serum 25–hydroxyvitamin D, calcium, and phosphorous concentrations, as well as fasting blood glucose and lipid profile.
Subjects were advised to regularly expose themselves to sunlight and increase intake of vitamin D–rich foods.
All measurements were repeated 6 and 12 months later.
At the initial baseline visit, the prevalence of both low high–density lipoprotein cholesterol and hypertension was significantly increased among patients with 25–vitamin D deficiency (P<.05), even after adjusting for sex and body mass index.
Overall prevalence of MetS patients by the modified National Health and Nutrition Examination Survey Adult Treatment Panel III definition decreased from 25.2% to 13.0%; and this was largely due to a parallel decrease in the prevalence of low high–density lipoprotein cholesterol, triglycerides, and hypertension.
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