Cryptococcal meningitis in HIV uninfected patients in Vietnam is due to a distinct AFLP-defined cluster of Cryptococcus neoformans var. grubii

Journal of Clinical Microbiology, 01/05/2011

Cryptococcal disease most commonly occurs in patients with underlying immune deficit, most commonly HIV infection, and is due to Cryptococcus neoformans var. grubii. Occasionally disease due to this variety occurs in apparently immunocompetent patients. The relationship between strains infecting immunosuppressed and immunocompetent patients is not clear. Two clusters of C. neoformans var. grubii VN1 are responsible for the majority of cases of cryptococcal meningitis in Vietnam. The distribution of these clusters differs according to the immune status of the host.

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