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See Latest ArticlesAntiplasmodial and cytotoxic activity of phloroglucinol derivatives from Hypericum erectum thunb
Phytotherapy Research, 02/03/10
Moon HI – Five phloroglucinol derivatives, otogirin (1), otogirone (2), erectquione A (3), erectquione B (4), and erectquione C (5) were isolated from the whole plants of H. erectum. Also, five compounds were evaluated for in vitro antiplasmodial activities as well as their cytotoxic potential on SK–OV–3 cancer cell line cells. Compounds 2, 4 showed notable growth inhibitory activity against chloroquine–sensitive strains of Plasmodium falciparum with IC50 values from 5.6 and 7.2 muM. This compound showed no significant cytotoxicity (IC50 > 150 muM) evaluated using SK–OV–3 cancer cell line cells.
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