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See Latest ArticlesDeath temporally related to the use of a beta adrenergic receptor antagonist in cocaine associated myocardial infarction
Journal of Medical Toxicology, 11/10/09
Fareed FN et al. – The administration of beta adrenergic receptor antagonists exacerbates cocaine–induced lethality in animals. In humans given smaller doses of cocaine, beta adrenergic receptor antagonists exacerbate coronary vasoconstriction. Both effects are presumed to occur through unopposed alpha adrenergic receptor agonism. Despite these data, actual cases describing adverse effects in cocaine users given beta adrenergic receptor antagonists are uncommon. This case supports the potential lethality of a cocaine–beta adrenergic receptor antagonist interaction.
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