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Transmembrane and Soluble Isoforms of Heparin-Binding Epidermal Growth Factor-Like Growth Factor Regulate Distinct Processes in the Pancreas
Gastroenterology, 10/28/09
Ray KC et al. – The work demonstrates that islet function depends on the ratio of cleaved to uncleaved HB–EGF and that the transmembrane intermediate, while deleterious to islet function, is necessary to restrict action of soluble HB–EGF away from surrounding tissue.
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