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Sperm, and not just the fluid it bathes in, can transmit HIV to macrophages, T cells, and dendritic cells, report a team led by Ana Ceballos at the University of Buenos Aires in Argentina. By infecting DCs, which carry the virus and potently pass it to T cells, sperm may play a leading role in spreading HIV. During sexual intercourse, HIV–infected men transmit HIV through their semen, which carries free–floating virus as well as HIV–infected leukocytes. Traces of HIV have been detected on sperm as well, but the role they play in viral transmission has been a matter of debate.

   

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