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See Latest ArticlesHomozygous P86S Mutation of the Human Glucagon Receptor Is Associated With Hyperglucagonemia, [alpha] Cell Hyperplasia, and Islet Cell Tumor
Pancreas, 10/26/09
Zhou C et al. – The authors report the first homozygous missense mutation in the human GCGR, which is associated with alpha cell hyperplasia and hyperglucagonemia. This mutation lowers the receptor's affinity to glucagon and decreases cyclic adenosine monophosphate production with physiological concentrations of glucagon. Thus, the P86S mutation in GCGR likely causes alpha cell hyperplasia and hyperglucagonemia.
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