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Epstein S et al. – Risedronate 150mg once monthly has demonstrated less reduction of BTM and non–inferior BMD gains versus daily, whereas 150mg once monthly ibandronate has demonstrated BTM suppression within the premenopausal range and BMD gains superior to the daily regimen. Furthermore, ibandronate has demonstrated antifracture efficacy with intermittent dosing in two pooled analyses. Risedronate has yet to demonstrate anti–fracture efficacy with an extended (intermittent) dosing regimen.

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