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Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer
BMC Gastroenterology, 10/21/09
Mockelmann N et al. – Variation in the innate immunity genes CARD4, CARD8 and CARD15 is unlikely to play a major role in the susceptibility to CRC in the German population. But, the authors report a significant disease contribution of CARD15 for CRC patients with very early disease manifestation, mainly driven by variant R702W.
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