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See Latest ArticlesBH3-only protein bid participates in the Bcl-2 network in healthy liver cells
Hepatology, 10/20/09
Hayashi N et al. – Bid, originally considered to be a sensor for apoptotic stimuli, is constitutively active in healthy liver cells and is involved in the Bak/Bax–dependent mitochondrial cell death pathway. Healthy liver cells are addicted to a single Bcl–2–like molecule because of BH3 stresses, and therefore special caution may be required for the use of the Bcl–2 inhibitor for cancer therapy.
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