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See Latest ArticlesVanoxerine: Cellular Mechanism of a New Antiarrhythmic
Journal of Cardiovascular Electrophysiology, 10/27/09
Lacerda AE et al. – Vanoxerine is a potent blocker of cardiac hERG, Na and Ca channels; block is strongly frequency–dependent especially for Na and Ca channels; and transmural dispersion of ventricular repolarization is unaffected. The multichannel block and repolarization uniformity resemble the effects of amiodarone, the exemplar atrial fibrillation drug. Vanoxerine is a completely different chemical and has none of amiodarone's toxic effects. Vanoxerine has characteristics of a potentially effective and safe antiarrhythmic.
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