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See Latest ArticlesFall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials
British Medical Journal, 10/09/09
Bischoff–Ferrari HA et al. – Supplemental vitamin D in a dose of 700–1000 IU a day reduced the risk of falling among older individuals by 19% and to a similar degree as active forms of vitamin D. Doses of supplemental vitamin D of less than 700 IU or serum 25–hydroxyvitamin D concentrations of less than 60 nmol/l may not reduce the risk of falling among older individuals.
Methods- The authors searched Medline, the Cochrane central register of controlled trials, BIOSIS, and Embase up to August 2008 for relevant articles.
- Only double blind randomised controlled trials of older individuals (mean age 65 years or older) receiving a defined oral dose of supplemental vitamin D (vitamin D3 (cholecalciferol) or vitamin D2 (ergocalciferol) or an active form of vitamin D or 1,25–dihydroxyvitamin D3 and with sufficiently specified fall assessment were considered for inclusion.
- Eight randomised controlled trials (n=2426) of supplemental vitamin D met the authors' inclusion criteria. Heterogeneity among trials was observed for dose of vitamin D (700–1000 IU/day v 200–600 IU/day; P=0.02) and achieved 25–hydroxyvitamin D3 concentration (25(OH)D concentration: <60 nmol/l v >= 60 nmol/l; P=0.005).
- High dose supplemental vitamin D reduced fall risk by 19%, whereas achieved serum 25(OH)D concentrations of 60 nmol/l or more resulted in a 23% fall reduction.
- Falls were not notably reduced by low dose supplemental vitamin D or by achieved serum 25–hydroxyvitamin D concentrations of less than 60 nmol/l.
- Two randomised controlled trials (n=624) of active forms of vitamin D met the authors' inclusion criteria. Active forms of vitamin D reduced fall risk by 22%.
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