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Update on Pelvic floor dysfunction
OBG Management, 10/06/09

Judd JP et al. – Combining an anticholinergic and behavioral therapy may treat urge incontinence more effectively than either modality alone in women who are dissatisfied with single therapy. Treatment with 5 mg/day oral extended–release oxybutynin in older patients with some cognitive impairment is well tolerated, the study’s findings suggest, with minimal risk of further cognitive decline or delirium over the short term. The potential that long–term therapy has to harm cognitive function remains, however; data on long–term treatment are needed to illuminate that area. The authors also address the importance of dosing, especially over time, and discuss the lower potential of newer–generation anticholinergics to produce cognitive impairment.

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