Nursing Medical News about Thyroid Diseases Drug Toxicity Phenytoin

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Phenytoin toxicity and thyroid dysfunction
New Zealand Medical Journal, 10/08/09

Betteridge T et al. – A 48–year–old woman with known epilepsy presented to the Emergency Department with a 1–day history of decreasing coordination, impaired speech, and recurrent falls. Phenytoin levels were measured and found to be grossly elevated at 170 mmol/L. A diagnosis of phenytoin toxicity was made and she was treated by withdrawing the medication. During admission she was found to be profoundly hypothyroid despite being on adequate thyroid replacement therapy. Normalisation of phenytoin levels was associated with return of euthyroidism. The interaction between phenytoin, thyroid function, and thyroid replacement therapy is discussed.

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Interindividual variability of drug transporters: Impact on opioid treatment in chronic renal failure
European Journal of Pain, 11/12/09 Relevance Score: 80%

Unusual presentation of iatrogenic phenytoin toxicity in a newborn
Journal of Medical Toxicology, 11/11/09 Relevance Score: 80%

Phenytoin-facilitated hypoglycaemia in ESRF
British Journal of Renal Medicine, 10/26/09 Relevance Score: 80%

Drug-Induced Steatohepatitis Leading to Cirrhosis: Long-Term Toxicity of Amiodarone Use
Seminars in Liver Disease, 10/16/09 Relevance Score: 80%

Rituximab in the Treatment of Thyroid Eye Disease: Science Fiction
Orbit - The International Journal on Orbital Disorders, Oculoplastic and Lacrimal Surgery, 11/12/09 Relevance Score: 79%