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Beryllium lymphocyte proliferation test surveillance identifies clinically significant beryllium disease
American Journal of Industrial Medicine, 08/18/09
Mroz MM et al. – At baseline, chronic beryllium disease (CBD) and beryllium sensitization (BeS) cases did not differ significantly in exposure time or physiology. CBD patients were more likely to have machined beryllium. Of CBD cases, 19.3% went on to require oral immunosuppressive therapy. At 30 years from first exposure, measures of gas exchange were significantly worse and total lung capacity was lower for CBD subjects. Machinists had faster disease progression as measured by pulmonary function testing and gas exchange. Medical surveillance for CBD identifies individuals at significant risk of disease progression and impairment with sufficient time since first exposure.
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