Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. Recommendations on the use of 18F-FDG PET in oncology 3. Use of Antiemetic Agents in Acute Gastroenteritis 4. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer 5. AHA Guidelines on Cardiac CT for Assessing Coronary Artery Disease
Your Article Summary
A double-blind, randomized, saline-controlled study of the efficacy and safety of Euflexxa® for treatment of painful osteoarthritis of the knee, with an open-label safety extension (the FLEXX trial)
Seminars in Arthritis and Rheumatism, 06/29/09
Altman RD et al. – Study demonstrates that Euflexxa (1% sodium hyaluronate; IA-BioHA) therapy resulted in significant osteoarthritis (OA) knee pain relief at 26 weeks compared with intra-articular saline (IA-SA). Subjects treated with IA-BioHA also experienced significant improvements in joint function, treatment satisfaction, and HRQoL.
Methods- FLEXX trial: assessing the safety and efficacy of IA-BioHA therapy for knee OA at 26 wks
- Subjects with chronic knee OA were randomized to 3 weekly IA injections IA-SA or IA-BioHA (20 mg/2 ml)
- Primary efficacy outcome: subject recorded difference in least-squares means between IA-BioHA and IA-SA following a 50-foot walk test, measured via 100-mm VAS
- Secondary outcome measures:
- Osteoarthritis Research Society International responder index
- Western Ontario McMaster University Osteoarthritis Index VA 3.1 subscales
- Patient global assessment
- Rescue medication, and
- Health-related quality of life (HRQoL) by the SF-36
- Safety assessed by monitoring and reporting vital signs, physical examination of the target knee following injection, adverse events, and concomitant medications
- 588 subjects randomized to either IA-BioHA (n=293) or IA-SA (n=295), with an 88% 26 wk completion rate
- No differences were noted between the treatment groups at baseline
- In the IA-BioHA group, mean VAS scores decreased by 25.7 mm, vs 18.5 mm in the IA-SA group
- This corresponded to a median reduction of 53% from baseline for IA-BioHA and a 38% reduction for IA-SA
- The difference in least-squares means was -6.6 mm
- Secondary outcome measures were consistent
- Both IA-SA and IA-BioHA injections were well tolerated, with a low incidence of AEs
- Injection-site reactions were reported by 1 (<1%) subject in the IA-SA group and 2 (1%) in the IA-BioHA group
Related Articles
Pain and rheumatology: An overview of the problem
European Journal of Pain, 11/18/09
Relevance Score: 62%
There Is Inadequate Evidence to Determine the Effectiveness of Nonpharmacological and Nonsurgical Interventions for Hand Osteoarthritis: An Overview of High-Quality Systematic Reviews
Physical Therapy, 11/10/09
Relevance Score: 45%
Discriminant Validity of the Western Ontario and McMaster Universities Osteoarthritis Index Physical Functioning Subscale in Community Samples With Hip Osteoarthritis
Archives of Physical Medicine and Rehabilitation, 10/22/09
Relevance Score: 45%
Clinical efficacy evaluation on electroacupuncture for osteoarthritis and observation on biomechanical indexes
Journal of Acupuncture and Tuina Science, 10/19/09
Relevance Score: 45%
Effect of nonsteroidal anti-inflammatory drug plasters for knee osteoarthritis in Japanese: a randomized controlled trial
Modern Rheumatology, 10/12/09
Relevance Score: 45%
Today in Clinical Pharmacology...keeping you current
Receive free subspecialty "5-minute updates" via email
Concomitant or adjuvant temozolomide with whole-brain irradiation for brain metastases: a meta-analysis
Anti-Cancer Drugs, 12/09/09
Developments in factor Xa inhibitors for the treatment of thromboembolic disorders
Medicinal Research Reviews, 12/09/09
Cyclooxygenase inhibitors: Scope of their use and development in cancer chemotherapy
Medicinal Research Reviews, 12/09/09
Today in Ortho/Rheum...keeping you current
Receive free subspecialty "5-minute updates" via email
Effectiveness of an ergonomic intervention on the productivity of workers with upper-extremity disorders - a randomized controlled trial
Scandinavian Journal of Work, Environment & Health, 12/09/09
Clinical observation of puncturing lumbar acupoints for knee joint pain
Journal of Acupuncture and Tuina Science, 12/09/09
Bone Turnover Markers and Prediction of Fracture: A Prospective Follow-Up Study of 1040 Elderly Women for a Mean of Nine Years
Journal of Bone and Mineral Research, 12/09/09
Sponsor
Article Search
Sponsor


See Latest Articles


