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Cox TJ - More and more, data point to cotesting as the screen of choice for women 30 years and older, with the screening interval extended to 3 years for any patient who tests negative on both HPV and Pap tests. These two important studies provide further evidence that testing for human papillomavirus (HPV) merits a prominent place in primary cervical cancer screening in developed and developing nations. Sankaranarayanan and colleagues found that a single round of HPV testing in a low-resource setting (rural India) significantly reduced the incidence of advanced cervical cancer and associated mortality. Castle and associates demonstrated that the number of HPV-positive findings among women 30 years and older was not excessive when the HPV and Pap tests were used together (cotesting). In addition, with cotesting, the screening interval for women who tested negative on both tests could be extended to 3 years.

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