Nursing Medical News about Sirolimus

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Growth failure associated with sirolimus: case report
Pediatric Nephrology, 06/12/09

Rangel GA et al. - SRL may have deleterious effects on growing children due its characteristic anti-proliferative and anti-angiogenic properties. Pediatric transplant recipients’ linear growth should be cautiously monitored while they are being given SRL.

Exclusive Author Commentary
Gema Ariceta, 06/27/09

The goal of this article was to alert about potential deleterious effects on linear growth in children caused by sirolimus (SRL). To date there are no reports of growth failure in pediatric patients treated with SRL. However, we are presenting an abstract describing new data in a case series of transplanted children with growth retartadation while receiving SRL, at the next meeting of the European Society of Pediatric Nephrology this fall. In our patient, the good news was her good response to rh-GH. Nevertheless, in those children transferred to SRL due to immunosupression-related malignancy , rh-GH may not be an option. We suggest that pediatric transplant recipients’ linear growth should be cautiously monitored while they are being given SRL.

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