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See Latest ArticlesBortezomib, paclitaxel, and carboplatin as a first-line regimen for patients with metastatic esophageal, gastric, and gastroesophageal cancer
Journal of Thoracic Oncology, 05/09/08
Jatoi A et al. - Three-drug regimen that consisted of bortezomib, paclitaxel, and carboplatin as prescribed in this trial in patients with metastatic adenocarcinoma of the esophagus, gastroesophageal junction, or gastric cardia does not merit further testing.
Methods- Study to explore the response rate of a first-line, three-drug regimen (bortezomib, paclitaxel, and carboplatin) in pts with metastatic adenocarcinoma of esophagus, gastroesophageal junction, or gastric cardia
- Pts were treated iv on a 21-d cycle with bortezomib 1.2 mg/m2 on d1, 4, and 8; paclitaxel 175 mg/m2 on d2; and carboplatin with an area under the curve of 6 on d2
- Pts received indefinite treatment unless they manifested tumor progression or severe AEs
- All were monitored for tumor response as well as other clinical outcomes
- 35 eligible pts with a median age of 59 yrs and an Eastern Cooperative Oncology Group performance score of 0, 1, and 2 in 60%, 34%, and 6% of pts, respectively
- Although this regimen was well tolerated, the tumor RR was lower than that anticipated at 23%
- Thereby prompting premature study closure
- There were no complete responses
- The median survival for the cohort was 8.9 mos
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