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Effects of physical training on bone mineral density in fertile women with idiopathic osteoporosis
Clinical Rheumatology, 05/09/08

Bergström I et al. - There is no evidence-based therapy for women with idiopathic osteoporosis. It is therefore important to elucidate the impact of moderate physical activity in this group of patients.

• A study to investigate whether moderate physical training can improve the bone mineral density (BMD) in women with idiopathic osteoporosis
• 10 pre-menopausal women (age: 24–44 yrs) diagnosed with idiopathic osteoporosis were enrolled
• The physical training program: 3 fast 30-min walks plus 1 or 2 sessions of 1-h training/wk during 1 yr
• All pts were given supplements of vitamin D and calcium
• BMD was measured in the femoral neck area and the lumbar spine by dual energy X-ray absorptiometry
• The measurements were performed at baseline and after 12 mos of training
• They were compared with the measurements at the time of diagnosis, 1–3 yrs before the study

• Mean BMD in 8 women who fulfilled 12 mo training had BMD at start 0.88 (0.08) g/cm2 in the spine and 0.76 (0.13) g/cm2 in the femoral neck
• The mean spine BMD increase was 0.031 g/cm2 (3.5%) after 1 yr of training
• The mean increment in BMD in the femoral neck was 0.007 g/cm2 (0.9%) after the intervention
• However, the bone loss during the 1- to 3-yr period from diagnosis to study start was, on average, 0.045 g/cm2 or 5.0% in the femoral neck thus indicating a positive indirect effect of the intervention

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