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See Latest ArticlesCalculate the QT interval in patients taking drugs for dementia
British Medical Journal, 09/18/07
Leitch, A., et al. - Doctors need to be aware of potential drug interactions with donepezil. Calculating the corrected QT interval may be a life saving arithmetical exercise when elderly patients are treated for dementia. About 3% of prescriptions in the United Kingdom represent non-cardiac drugs with proarrhythmic potential. The drugs associated with prolonged QT interval include antiarrhythmics, antihistamines, antimicrobials, tricyclic antidepressants, and selective serotonin re-uptake inhibitors. QT prolongation with acetylcholinesterase inhibitors for dementia (rivastigmine) has been reported. Adverse effects reported for donepezil include bradycardia (uncommon) and heart block (rare)
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