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Clinical Trial Evaluating Amoxicillin and Clarithromycin Hydrogels (Chitosan-polyacrylic Acid Polyionic Complex) for H. pylori Eradication
Journal of Clinical Gastroenterology, 08/29/06
Gisbert, Javier P. PhD, et al. - It has been suggested that enhancement of amoxicillin or clarithromycin concentration at the gastric tissue may improve the anti-Helicobacter pylori effect of these drugs...Conclusions: Although dried polyionic complexes could serve as suitable candidates for amoxicillin and clarithromycin site-specific delivery in the stomach, its addition does not increase the eradication efficacy of the generally prescribed proton pump inhibitor plus amoxicillin and clarithromycin regimen
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