Molecular cloning of a novel secreted peptide, INM02, and regulation of its expression by glucose
Wang X et al. - Experiments on both MIN6 cells and intact isolated islets demonstrate that INM02 mRNA levels are increased more than 3-fold by high glucose (25 mM) when compared with low glucose (5.5 mM). ELISA analysis shows that secretion of INM02 is significantly augmented by high glucose in vitro. It is speculated that as a novel secreted protein, INM02 is associated with functions of pancreatic islets, especially of beta cells. [more...]
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