L-carnitine levels have clinical significance in non-APOE4 carriers with mild AD
As reported in the Journal of Alzheimers Disease, the CSF L-carnitine levels are decreased in patients with early Alzheimers disease (AD) who are non-APOE4 carriers. Further, the L-carnitine levels are correlated with Aβ42 and the MMSE score. It is suggested that L-carnitine supplementation may be beneficial in non-APOE4 carriers with mild AD.
Risk factors for suicidal ideations in bipolar disorder
As reported in Bipolar Disorders, the following risk factors were associated with suicidal ideations in patients with bipolar disorder (n=130): grade of severity of current episode (OR=22.601); family history of suicide attempt (OR=18.06); preceding life event (OR=3.797); and past history of suicidal event (OR=3.11).
Chronic HCV infections are under-reported
As reported in Clinical Infectious Diseases, of 12M death certificates only one-fifth of the 0.5% of patients with HCV had HCV listed on the death certificate. Moreover, two-thirds of the patients had pre-mortem signs of chronic liver disease.