Cisplatin monotherapy effective in pediatric high-risk hepatoblastoma
As reported in the Journal of Pediatric Hematology/Oncology, treatment of children with high-risk hepatoblastoma (n=14) with cisplatin monotherapy was as effective as cisplatin + doxorubicin combination therapy, but with less toxicity. The complete resection rate was 78.6%, the event-free survival rate was 81.8%, and the OS rate was 100%.
Mean platelet volume predicts silent cerebral infarction
As reported in the Internal Medicine Journal, the mean platelet volume is increased in patients with a silent cerebral infarction than in those without (10.4 vs. 9.2 fL). The OR for silent cerebral infarction was 7.822 in patients in the highest mean platelet volume quartile compared to the lowest quartile.
TNFR1 predicts all-cause mortality in diabetic kidney disease
As reported in Diabetes Care, type 2 diabetics (n=522) with diabetic kidney disease (eGFR< 60 or urinary albumin-to-creatinine ratio > 30 mg/mmol) with TNFR1 levels in the highest quartile were at increased risk of all-cause mortality compared to diabetics with TNFR1 levels in the lowest quartile (aHR = 2.98). One hundred ninety-six deaths occurred in 48 months of follow-up.