Testosterone exerts selective anti-inflammatory effects on human skin mast cells in a cell subset dependent manner
Experimental Dermatology, 08/17/2012
Guhl S et al. – Effector functions of human skin mast cells (MCs) are modulated by androgens in a gene–selective and MC subset–specific fashion. Possibly, MCs from females are more susceptible to testosterone. The authors also demonstrate that MC IL–6 production is highly variable among individuals.