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Vitamin A deficiency alters airway resistance in children with acute upper respiratory infection
Pediatric Pulmonology, 08/03/2012
Amaral CT et al. – Vitamin A contributes to preservation of airway function during and in recovery after upper respiratory infection in children.
Methods- This is a case control study of children, age 4–6 years and grouped as: URI, (n = 74), URI and wheezing, (URI-wheezing, n = 52), and healthy controls (n = 51).
- Vitamin A and total respiratory resistance (TRR) were assessed using the modified relative dose response (MRDR) and forced oscillometry, respectively.
- Children with URI and URI-wheezing had lower retinol, 32.4 ± 13.12 and 18.3 ± 6.83 μg/dl respectively, compared to controls, 56.9 ± 29.82 μg/dl (ANOVA, P < 0.001).
- The MRDR was elevated in children in the URI or URI-wheezing groups 0.066 ± 0.045 and 0.021 ± 0.021, respectively, compared to controls 0.007 ± 0.006 (ANOVA, P < 0.0001).
- The TRR in the URI and URI-wheezing groups differed from controls.
- During convalescence, the TRR failed to decline in the URI-group only when the MRDR was >0.06. In the URI-wheezing group, TRR declined independently of retinol and MRDR.