Vitamin D and diabetes in Koreans: analyses based on the Fourth Korea National Health and Nutrition Examination Survey (KNHANES), 2008-2009
Diabetic Medicine, 08/08/2012
Rhee SY et al. – The findings suggest that vitamin D deficiency, possibly involving altered insulin sensitivity, is associated with an increased risk for diabetes mellitus in the Korean population.Methods
- Authors analysed the glucose tolerance status and serum 25–hydroxyvitamin D concentrations in 12263 subjects >19 years old who were registered for the Korea National Health and Nutrition Examination Survey, 2008–2009.
- Various demographic variables such as gender, age, season, resident area, physical activity, smoking, alcohol, marital status, education and occupation were associated with serum 25–hydroxyvitamin D concentrations.
- After adjusting for these variables as confounders, 25–hydroxyvitamin D concentrations in subjects with diabetes were significantly lower than those in subjects with normal glucose tolerance and those with impaired fasting glucose (P=0.005).
- Compared with the ≥75 nmol/l subgroup of serum 25–hydroxyvitamin D concentration, the odds ratios and 95% confidence intervals for'diabetes mellitus were 1.206 (95% CI 0.948–1.534) in the 50– to 74–nmol/l subgroup, 1.339 (1.051–1.707) in the 25–'to'49–nmol/l subgroup and 1.759 (1.267–2.443) in the < 25–nmol/l subgroup.
- Compared with the serum ≥ 75–nmol/l 25–hydroxyvitamin D subgroup, serum insulin and homeostasis model assessment 2%B, a marker of insulin secretory capacity, were significantly higher, and homeostasis model assessment 2%S, a marker of insulin sensitivity, was significantly lower in the < 25– and 25– to 49–nmol/l serum 25–hydroxyvitamin D subgroups than those in the other subgroups (P<0.001).