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Prevalence of the metabolic syndrome in patients with borderline personality disorder: results from a cross-sectional study
European Archives of Psychiatry and Clinical Neuroscience,
Clinical Article
Kahl KG et al. – The results demonstrate an increased metabolic syndrome rate, dysregulated glucose and lipid metabolism in patients with borderline personality disorder.
Methods- One hundred and thirty–five BPD patients according to DSM–IV diagnostic criteria were compared to 1009 subjects from primary care.
- The authors used the American Heart Association/National Heart, Lung and Blood Institute criteria to determine the rate of MetS.
- The age–standardized prevalence of MetS was more than double in patients with BPD compared to comparison subjects (23.3 vs. 10.6 %, p < 0.05).
- Regarding individual MetS criteria, hyperglycemia was significantly more prevalent in both genders (p < 0.05).
- Abdominal obesity (p < 0.05) and hypertriglyceridemia (p < 0.05) were significantly higher only in women with BPD.
- Within BPD patients, an increased rate of MetS was associated with higher BMI (p = 0.004), age (p = 0.03), treatment with second–generation antipsychotics (quetiapine, olanzapine and clozapine; p = 0.032), dysthymia (p = 0.031), panic disorder (p = 0.032), benzodiazepine dependency (p = 0.015) and binge eating disorder p = 0.02).