Overwhelming Post-splenectomy Infection (OPSI): A Case Report and Review of the Literature
The Journal of Emergency Medicine, 06/26/2012
Morgan TL et al. – Rapid identification of patients at risk for Overwhelming post–splenectomy infection (OPSI), followed by administration of intravenous antibiotics, usually vancomycin and ceftriaxone, combined with early goal–directed therapy, are the keys to successful treatment. If initiated early in the patient's course, the 70% mortality rate can be reduced to the 10–40% range.