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Growth during puberty in cystic fibrosis: a retrospective evaluation of a French cohort
Archives of Diseases in Childhood, 06/26/2012
Bournez M et al. – In this cohort, children with cystic fibrosis (CF) had a normal age of onset of puberty and pubertal spurt, with a low PHV. Puberty contributed less to final adult height, and neither BMI nor FEV1 had a significant effect on pubertal height gain.
Methods- Retrospective data were drawn from the French CF registry from 1999 to 2004. Height, weight and forced expiratory volume in 1 s (FEV1) were recorded annually.
- Growth and velocity curves were compared with reference curves.
- 729 children with CF were included. In girls, height was similar to the reference population until age 11.
- Age at onset of puberty was the same as in reference girls.
- The pubertal spurt was lower than reference values and contributed less to the final adult height.
- In boys, the mean height was close to the reference mean until age 14 and was thereafter lower.
- Age at growth acceleration was similar to that in reference boys, but with an impaired peak height velocity (PHV).
- No correlations were found between body mass index (BMI) and PHV.